Detecting Trace Polymorphs with Powder X-Ray Diffraction (PXRD)
Powder X-ray diffraction (PXRD) processes are commonly used within the chemicals industry to detect traces of polymorphs.
The need for better limits of detection (LOD) is driving advances in detector and optical technologies. While classical PXRD configurations were purported to have an LOD in the range of 0.5%-2%, modern systems with specially designed optics can have detection limits below 0.1%, up to an order of magnitude below the commonly believed detection limit.
This document explores a number of ways that today’s modern, laboratory-based PXRD instrumentation and advanced software can greatly assist pharmaceutical scientists in their quest to develop high-quality, stable products and accelerate their speed to market.
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