Malvern Panalytical Analytical Solutions for Manufacturing Productivity

Malvern Instruments

Malvern Panalytical provides a wide range of material characterisation systems used throughout the chemicals and chemical processing industries.

Our cutting-edge systems facilitate the precise measurement of an extensive list of parameters depending on customers’ individual needs, including particle size, shape, rheological properties and elemental concentration, allowing users to optimise their products and better predict how they will behave during use.

Chemical data collection and analysis

Malvern Panalytical helps to solve complex analytical challenges and provide data for optimising products and processes, predicting how products will behave in use and improving productivity. They are used for materials ranging from polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high-concentration slurries.

The parameters they measure include:

  • Particle shape, size and concentration, and zeta potential
  • Protein charge
  • Molecular weight, mass, conformation, interactions and stability
  • Rheological properties
  • Chemical identification

Laser diffraction for measuring particle size and size distributions

Laser diffraction is a widely used particle sizing technique for materials from sub-micron to several millimetres in size.

Mastersizer 3000 is a laboratory instrument that delivers rapid, accurate particle size distributions for wet and dry dispersions. It offers exceptional performance in a small footprint and delivers highly reliable, operator-independent measurements.

Insitec systems provide online continuous particle size analysis for efficient, cost-effective monitoring and control of industrial processes. They are suitable for process streams from dry powders to hot, sticky slurries, sprays and emulsions.

Spraytec measures spray particle and droplet size distributions in real-time during the course of a spray event, providing data for efficient development of sprays and aerosols. Flexible configuration enables droplet size measurement for a wide range of products.

Dynamic light scattering for characterising submicron particle dispersions

Dynamic light scattering (DLS) is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles in the submicron region, with the latest technology measuring less than 1nm. It is typically used to characterise particles, emulsions or molecules dispersed or dissolved in a liquid.

The Zetasizer series measures from less than 1nm to several microns using DLS. Zetasizer Nano systems also measure zeta potential and electrophoretic mobility using electrophoretic light scattering, and molecular weight using static light scattering.

Nanoparticle tracking analysis to visualise and measure nanoparticles

Malvern Panalytical’s NanoSight systems use nanoparticle tracking analysis (NTA) to characterise nanoparticles from 10nm to 2,000nm in solution. Each particle is individually but simultaneously analysed by direct observation and measurement of diffusion events.

This particle-by-particle methodology produces high-resolution results for particle size distribution and concentration, with visual validation. A fluorescence mode provides differentiation of labelled or naturally fluorescing particles.

Particle shape and chemical identification

Particle shape and size can significantly impact the performance and process handling of particulate materials.

It may influence properties such as the bioavailability of drug particles in tablets and suspensions, material strength in metal and ceramic sintered components, printing quality of toners and solder pastes, packing behaviour of chromatography columns, quality of mineral-based coatings finishes and the cutting performance of silicon carbide (SiC) abrasives for solar panel manufacture.

Morphologi imaging-based systems provide particle size and shape measurement for dispersed samples from 0.5 microns to several millimetres.

The addition of Raman spectroscopy in the Morphologi G4-ID system combines automated imaging with chemical identification of individual particles in a technique known as morphologically directed Raman spectroscopy (MDRS).This enables possible chemical identification of individual particles within a multi-component blend.

Triple detection GPC to identify polymer molecular weight, size and structure

Also known as size exclusion chromatography (SEC), gel permeation chromatography (GPC) first separates dissolved macromolecules by size, based on their elution from a gel-filled chromatography column.

Light scattering, viscometer and concentration detectors then measure absolute molecular weight, molecular size and intrinsic viscosity, providing information on macromolecular structure, conformation, aggregation and branching.

These parameters are fundamental to polymer performance in multiple applications. Information from Malvern Panalytical’s GPC / SEC systems helps in controlling the strength, toughness and other performance attributes of materials and tailoring the behaviour of polymer-based products.

Measurement of rheological properties

Rotational, capillary and microfluidic flow rheometers from Malvern Panalytical enable measurement of flow and deformation properties of materials, from dilute, weakly structured solutions to concentrated gels, slurries and pastes. The resulting data is used to understand and control product stability and performance.

Kinexus rotational rheometers are sensitive enough to measure the viscosity of dilute polymer solutions, yet sufficiently robust enough to measure viscoelasticity of high modulus polymers or composites. Unique software provides total flexibility of test set-up for research and development, through to standard operating procedure (SOP) driven testing for more routine rheological requirements.

Rosand capillary rheometers characterise the rheology of materials by extrusion under the high pressures, shear rates and temperatures relevant to processing. Materials include polymer melts, ceramics, foodstuffs, inks and coatings.

About Malvern Panalytical

Malvern Panalytical was formally established on 1 January 2017 by the merger of UK company Malvern Instruments and Netherlands-based PANalytical, along with its subsidiaries ASD and Claisse.

The company has a global sales and service presence and currently employs more than 2,000 staff worldwide, while operating a number of research and manufacturing sites across Europe, the US and China.

Malvern Panalytical is dedicated to the development of innovative materials characterisation tools for a wide variety of industrial applications in order to deliver valuable actionable insight and assist in the creation of high-quality products.

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Press Release

Malvern Panalytical Webinars: April 2018

Material characterisation solutions specialist Malvern Panalytical is pleased to announce that the company will be running a series of webinar sessions during April 2018.

Product and Services
White Papers

How Malvern Helped Rutgers University Optimise its Polymer Scaffold Fabrication Activities

The processing of degradable polymers poses a number of unique challenges.

Address
Malvern Instruments Ltd.

Enigma Business Park

Grovewood Road

Malvern

WR14 1XZ

Worcestershire

United Kingdom

+44 1684 892456 +44 1684 892789 www.malvern.com Malvern Store

Malvern Panalytical Images

Products and Services

Mastersizer Range

The Mastersizer range comprises easy-to-use, accurate and reliable particle size analysers. The high-performance devices cover particle sizes ranging from nanometers to millimetres, providing reliable independent measurements.

MicroCal PEAQ-DSC: Manual

MicroCal PEAQ-DSC systems deliver highly sensitive, easy-to-use microcalorimetry that reduce the time and cost associated with stability testing and comparability analysis.

MicroCal PEAQ-DSC: Product Range

MicroCal PEAQ-DSC microcalorimeters are effective and easy-to-use tools that facilitate thermal stability characterisation of proteins and other biomolecules, primarily for biopharmaceutical development and manufacturing applications.

m-VROCi

The Malvern m-VROCi utilizes unique microfluidic viscometer / rheometer on a chip technology to provide high-resolution viscosity measurements into the ultra-high shear rate regime.

MicroCal PEAQ-DSC: Automated

MicroCal PEAQ-DSC automated systems provide sensitive, high throughput protein stability analysis with low sample consumption in an automated, fully integrated platform to facilitate maximum productivity.

Viscosizer TD

Malvern Viscosizer TD is an automated biophysical characterisation tool utilising Taylor Dispersion Analytics and providing ultra-low volume, solution-based molecular size and stability measurement capabilities, combined with Poiseuille flow for relative viscosity assessment.

Viscotek Range

The Viscotek range comprises complete systems, software and detectors, which are all supported by Malvern's worldwide network to provide training and advice.

Viscotek UV Detector

Accurate measurement of the polymer or protein concentration profile is essential to good molecular weight or structure data. The high-stability Viscotek UV detector is ideally suited for multi-detection GPC/SEC.

Zetasizer Range

Zetasizer AT

Malvern's Zetasizer AT brings the industry leading Dynamic Light Scattering (DLS) technology of the Zetasizer Nano to the process development and manufacturing arena, enabling real time monitoring of nanoscale particle processes online.

Kinexus Range

Kinexus is a next-generation rotational rheometer platform that was developed according to industry feedback.

Related Projects



Press Release

13th April 2018

Material characterisation solutions specialist Malvern Panalytical is pleased to announce that the company will be running a series of webinar sessions during April 2018.

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14th February 2018

Malvern Panalytical is pleased to announce the launch of its new range of Morphologi® particle characterisation systems, Morphologi 4 and Morphologi 4-ID.

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30th January 2018

Malvern Panalytical is pleased to announce the launch of the new Epsilon 4 benchtop analytical tool, which delivers fast and reliable at-line elemental analysis for chemical applications.

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25th January 2018

Dynamic Light Scattering (DLS), alternatively known as either Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering, is an innovative method of analysing the size of small particles within a solution at the sub-micron level.

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19th January 2018

PANalytical is pleased to announce that the first of the company's 2018 series of webinars will take place on 22 February, focussing on the application study of precision agriculture and spectral signatures.

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12th January 2018

Malvern is pleased to announce that the company will be demonstrating its innovative new nanoparticle characterisation platform known as NanoSight NS300 at a live launch event, which is set to take place on 18 January.

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4th December 2017

Malvern Panalytical has announced the launch of a collaborative project that aims to support the development of existing and next generation biopharmaceutical products.

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3rd September 2017

Malvern is pleased to announce that the company will be conducting a webinar entitled 'Transforming the Future of Particle Characterisation: Clarity by Design' on 4 October.

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31st August 2017

Malvern PANalytical is pleased to announce it will be hosting a webinar entitled 'Rheology of Soft Matter: Gels and Soft Glass Transition' on 14 September.

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17th July 2017

Leading analytical X-ray instrumentation and software provider PANalytical is pleased to unveil its latest solution, the new Epsilon 1 X-ray fluorescence (XRF) spectrometer.

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10th July 2017

Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.

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3rd July 2017

Malvern is set to host a series of webinar sessions throughout July and August.

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7th June 2017

Malvern is pleased to announce it will be hosting a number of webinar sessions throughout June, discussing the merits and applications of number of chemical particle analysis methods.

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25th April 2017

Comparative analytical data is at the foundation of any successful biosimilarity programme.

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6th April 2017

As its name implies, a viscometer is used to measure the viscosity of a given fluid.

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7th March 2017

Malvern Instruments will be running two webinar sessions this month; the first will discuss the potential applications of differential scanning calorimetry in protein characterisation, while the second will cover the use of particle size analysis in cement plant operations.

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20th February 2017

On 21 February, Malvern will host the unveiling of the next major step forward in protein stability characterisation for the regulated environment: the new MicroCal PEAQ-DSC.

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19th February 2017

The efficiency of a particular powder bed additive manufacturing process, and the overall quality of the finished components, is to a large extent dependent on the packing density and flow behaviour of the metal powders involved.

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11th December 2016

To celebrate the knowledge, support and dedication of our employees we are introducing our first live panel discussion to help you solve your current challenges. We invite you to write in your questions, comments, feedback and wish lists for our panel to answer.

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4th December 2016

Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for characterizing natural and synthetic polymers.

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8th November 2016

The market for batteries is rapidly growing, and the increased demand for portable electronic devices, including mobile phones and laptops requires greater advances in battery technology in order to provide a lightweight, long-lasting and stable power source.

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7th November 2016

The self-association characteristics of molecules in dilute solutions can provide an assessment of stability at an early stage in development.

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2nd November 2016

Paints or coatings, similar to many commercial products, must be optimized for their end use performance, which for paints and coatings includes leveling behavior, pigment dispersability, sag resistance, applicator loading and film thickness, all of which depend on a coatings rheological behavior.

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10th October 2016

Malvern has announced it will be demonstrating its new nanoparticle size and concentration measurer NanoSight NS3000, which uses Nanoparticle Tracking Analysis (NTA).

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7th September 2016

Malvern is to host a webinar about zeta potential and its importance when controlling formulation stability and product performance.

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18th August 2016

In recent news, the FDA has used key data generated on the Malvern Morphologi G3-ID system to approve the first generic nasal spray drug product containing mometasone furoate. The primary challenge with this approval was proving bioequivalence compared to the innovator product.

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7th June 2016

Malvern Instruments has launched the new Zetasizer AT, a robust, online, automated analyzer that uses dynamic light scattering (DLS) to automatically measure the size of nanoparticles in suspensions and emulsions.

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4th March 2016

Researchers working on the European Metrology Research Project NanoChOp (chemical and optical characterization of nanomaterials in biological systems), funded by EURAMET, have concluded that the NanoSight Nanoparticle tracking analysis system from Malvern Instruments offers unique insight into the behavior of nanoparticles in biological systems.

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14th December 2015

The latest software release along with an expansion of the global technical specialist team, highlight Malvern Instruments' ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities.

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3rd December 2015

A collaboration between UK firm Malvern Instruments and California-based Bio-Rad has developed new analytical tools for the rapid identification of unknown particles.

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2nd November 2015

Insights shared by William Bernt, director of Particle Characterization Laboratories, highlight the transformative impact of adding a Malvern NanoSight Nanoparticle Tracking Analysis (NTA) system to the analytical toolkit for nanoparticles.

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14th October 2015

Malvern's new tools for specific analytical challenges in biopharma development will take centre stage at AAPS Annual Meeting and Exposition 2015, in Orlando, US.

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1st October 2015

Malvern Instruments has established a new biopharmaceutical applications laboratory in the heart of San Diego's biotechnology cluster.

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18th September 2015

Insight from CP Kelco, a global leader in the speciality hydrocolloids market, provides a blueprint for the intelligent, cost-efficient deployment of gel permeation / size exclusion chromatography (GPC/SEC) in biopolymer manufacture.

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18th September 2015

Malvern Instruments has launched a new and improved rSolution platform on their Kinexus rotational rheometer to help customers use rheological measurements more effectively.

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24th February 2015

Analytical systems from Malvern Instruments are now used routinely to advance inkjet formulation at Domino Printing Sciences in the UK, one of the world's leading printing technology companies.

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Regional Offices

Malvern Instruments Ltd.

Enigma Business Park

Grovewood Road

Malvern

WR14 1XZ

Worcestershire

United Kingdom

+44 1684 892456 +44 1684 892789 www.malvern.com Malvern Store
Malvern Canada

4995 Levy Street

Montreal

Quebec H4R 2N9

Canada

+1 800 932 0101 +1 508 768 6403
Malvern Instruments China

Unit 101, XinAn Plaza

Building 13, No 99 Tianzhou Road

Shanghai 200233

China

+86 40 0630 6902 +86 21 6113 3778
Malvern Instruments Nordic AB

Korskildelund 6

DK-2670 Greve

Denmark

+ 45 36 91 51 00 + 45 36 91 51 01 www.malvern.com
Malvern Instruments Nordic OY

Kumitehtaankatu 5

Klondyke

FI-04260 Kerava

Finland

+358 9 68 99 52 31 +358 9 68 99 52 32
Malvern Instruments SA

Parc Club de l'Université

30 Rue Jean Rostand

91893 Orsay Cedex

France

+33 1 6935 1800 +33 1 6019 1326 www.malverninstruments.fr
Malvern Instruments GmbH

Marie-Curie-Str. 4/1

71083 Herrenberg

Germany

+49 7032 97770 +49 7032 77854 www.malvern.de
Malvern Aimil Instruments Pvt Ltd

BSEL Tech Park

11th Floor, Sector - 30A, opposite Vashi Railway Station

Vashi

Navi Mumbai 400 705

India

+91 22 3964 6600 +91 22 3964 6666
Malvern Instruments Japan

North Bldg 511 Kobe International Business Center

5-5-2 Minatojimaminami-machi Chuo-ku, Kobe-shi

Hyogo Prefecture 650-0047

Japan

+81 78 306 3806 +81 78 306 3807 www.malvern.jp
Malvern Korea Division of Spectris Korea

Malvern Instruments Korea

7F SH Energy B/D, 16-6 Sunae-Dong

Bundang-Gu, Seongnam-City

Kyeonggi-Do

South Korea

+82 31 786 0840 +82 31 786 0950 www.malvern.co.kr
Malvern Instruments

Av. De La Industria No 300

San Pedro Garza Garcia C.P. 66279

Mexico

+52 55 56 84 65 48
Malvern Instruments Nordic AB.

Lokkeasveien 22A

NO-3138 Skallestad

Norway

+47 33 38 7328 +47 33 38 7329
Malvern Instruments Nordic AB

Vallongatan 1

752 28 Uppsala

Sweden

+46 18 55 24 55 +46 18 55 11 14
Malvern Instruments Inc.

117 Flanders Road

Westborough

MA 01581-1042

United States of America

+1 508 768 6400 +1 508 768 6403 +1 508 768 6401

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