Number and Volume Size Distributions10 October 2016 by Malvern Instruments
The nature of a particle size distribution analysis is dependent upon the manner in which the particles involved are weighted. Three different distribution weighting mechanisms are commonly used: number, volume and intensity. An intensity distribution weights particles according to the amount of light they scatter, a volume distribution weights particles according to the volume they occupy, and a number distribution weights particles according to their concentration.
This application note demonstrates practically the information that each distribution gives when applied to a protein formulation, and how the values generated by the different weightings can be used in conjunction to give a better idea of the nature of a sample.
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Number and Volume Size Distributions