Malvern Panalytical Analytical Solutions for Manufacturing Productivity
Malvern Panalytical provides a wide range of material characterisation systems used throughout the chemicals and chemical processing industries.
Our cutting-edge systems facilitate the precise measurement of an extensive list of parameters depending on customers’ individual needs, including particle size, shape, rheological properties and elemental concentration, allowing users to optimise their products and better predict how they will behave during use.
Chemical data collection and analysis
Malvern Panalytical helps to solve complex analytical challenges and provide data for optimising products and processes, predicting how products will behave in use and improving productivity. They are used for materials ranging from polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high-concentration slurries.
The parameters they measure include:
- Particle shape, size and concentration, and zeta potential
- Protein charge
- Molecular weight, mass, conformation, interactions and stability
- Rheological properties
- Chemical identification
Laser diffraction for measuring particle size and size distributions
Laser diffraction is a widely used particle sizing technique for materials from sub-micron to several millimetres in size.
Mastersizer 3000 is a laboratory instrument that delivers rapid, accurate particle size distributions for wet and dry dispersions. It offers exceptional performance in a small footprint and delivers highly reliable, operator-independent measurements.
Insitec systems provide online continuous particle size analysis for efficient, cost-effective monitoring and control of industrial processes. They are suitable for process streams from dry powders to hot, sticky slurries, sprays and emulsions.
Spraytec measures spray particle and droplet size distributions in real-time during the course of a spray event, providing data for efficient development of sprays and aerosols. Flexible configuration enables droplet size measurement for a wide range of products.
Dynamic light scattering for characterising submicron particle dispersions
Dynamic light scattering (DLS) is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles in the submicron region, with the latest technology measuring less than 1nm. It is typically used to characterise particles, emulsions or molecules dispersed or dissolved in a liquid.
The Zetasizer series measures from less than 1nm to several microns using DLS. Zetasizer Nano systems also measure zeta potential and electrophoretic mobility using electrophoretic light scattering, and molecular weight using static light scattering.
Nanoparticle tracking analysis to visualise and measure nanoparticles
Malvern Panalytical’s NanoSight systems use nanoparticle tracking analysis (NTA) to characterise nanoparticles from 10nm to 2,000nm in solution. Each particle is individually but simultaneously analysed by direct observation and measurement of diffusion events.
This particle-by-particle methodology produces high-resolution results for particle size distribution and concentration, with visual validation. A fluorescence mode provides differentiation of labelled or naturally fluorescing particles.
Particle shape and chemical identification
Particle shape and size can significantly impact the performance and process handling of particulate materials.
It may influence properties such as the bioavailability of drug particles in tablets and suspensions, material strength in metal and ceramic sintered components, printing quality of toners and solder pastes, packing behaviour of chromatography columns, quality of mineral-based coatings finishes and the cutting performance of silicon carbide (SiC) abrasives for solar panel manufacture.
Morphologi imaging-based systems provide particle size and shape measurement for dispersed samples from 0.5 microns to several millimetres.
The addition of Raman spectroscopy in the Morphologi G4-ID system combines automated imaging with chemical identification of individual particles in a technique known as morphologically directed Raman spectroscopy (MDRS).This enables possible chemical identification of individual particles within a multi-component blend.
Triple detection GPC to identify polymer molecular weight, size and structure
Also known as size exclusion chromatography (SEC), gel permeation chromatography (GPC) first separates dissolved macromolecules by size, based on their elution from a gel-filled chromatography column.
Light scattering, viscometer and concentration detectors then measure absolute molecular weight, molecular size and intrinsic viscosity, providing information on macromolecular structure, conformation, aggregation and branching.
These parameters are fundamental to polymer performance in multiple applications. Information from Malvern Panalytical’s GPC / SEC systems helps in controlling the strength, toughness and other performance attributes of materials and tailoring the behaviour of polymer-based products.
Measurement of rheological properties
Rotational, capillary and microfluidic flow rheometers from Malvern Panalytical enable measurement of flow and deformation properties of materials, from dilute, weakly structured solutions to concentrated gels, slurries and pastes. The resulting data is used to understand and control product stability and performance.
Kinexus rotational rheometers are sensitive enough to measure the viscosity of dilute polymer solutions, yet sufficiently robust enough to measure viscoelasticity of high modulus polymers or composites. Unique software provides total flexibility of test set-up for research and development, through to standard operating procedure (SOP) driven testing for more routine rheological requirements.
Rosand capillary rheometers characterise the rheology of materials by extrusion under the high pressures, shear rates and temperatures relevant to processing. Materials include polymer melts, ceramics, foodstuffs, inks and coatings.
About Malvern Panalytical
Malvern Panalytical was formally established on 1 January 2017 by the merger of UK company Malvern Instruments and Netherlands-based PANalytical, along with its subsidiaries ASD and Claisse.
The company has a global sales and service presence and currently employs more than 2,000 staff worldwide, while operating a number of research and manufacturing sites across Europe, the US and China.
Malvern Panalytical is dedicated to the development of innovative materials characterisation tools for a wide variety of industrial applications in order to deliver valuable actionable insight and assist in the creation of high-quality products.
Products and Services
The Mastersizer range comprises easy-to-use, accurate and reliable particle size analysers. The high-performance devices cover particle sizes ranging from nanometers to millimetres, providing reliable independent measurements.
MicroCal PEAQ-DSC: Manual
MicroCal PEAQ-DSC systems deliver highly sensitive, easy-to-use microcalorimetry that reduce the time and cost associated with stability testing and comparability analysis.
MicroCal PEAQ-DSC: Product Range
MicroCal PEAQ-DSC microcalorimeters are effective and easy-to-use tools that facilitate thermal stability characterisation of proteins and other biomolecules, primarily for biopharmaceutical development and manufacturing applications.
The Malvern m-VROCi utilizes unique microfluidic viscometer / rheometer on a chip technology to provide high-resolution viscosity measurements into the ultra-high shear rate regime.
MicroCal PEAQ-DSC: Automated
MicroCal PEAQ-DSC automated systems provide sensitive, high throughput protein stability analysis with low sample consumption in an automated, fully integrated platform to facilitate maximum productivity.
Malvern Viscosizer TD is an automated biophysical characterisation tool utilising Taylor Dispersion Analytics and providing ultra-low volume, solution-based molecular size and stability measurement capabilities, combined with Poiseuille flow for relative viscosity assessment.
The Viscotek range comprises complete systems, software and detectors, which are all supported by Malvern's worldwide network to provide training and advice.
Viscotek UV Detector
Accurate measurement of the polymer or protein concentration profile is essential to good molecular weight or structure data. The high-stability Viscotek UV detector is ideally suited for multi-detection GPC/SEC.
How Malvern Helped Rutgers University Optimise its Polymer Scaffold Fabrication Activities
The processing of degradable polymers poses a number of unique challenges.
Studying the Applications and Characterisation of Gold Nanoparticles by Nanoparticle Tracking Analysis
Gold nanoparticles are one of the most popular and extensively researched types of nanoparticle; a Google Scholar search of the term results in over 500,000 hits.
A Basic Introduction to Rheology
Rheology is as much about the deformation of solid-like materials.
Key Considerations When Purchasing an Advanced GPC/SEC system
Buying a new piece of laboratory equipment is always a big decision. Many thousands of dollars are often being invested based on relatively little information.
Optimising Metal Powders for Application in Additive Manufacturing Processes
Additive manufacturing (AM) processes have undergone a significant transition in recent years from a simple prototyping solution into an innovative, economically expedient method of component production.
A Guide to Understanding Yield Stress Measurements
The term 'yield stress characteristic' relates to a property present in a number of complex viscous fluids, whereby the liquid is unable to flow unless the stress applied exceeds a certain pressure.
Common Dynamic Light Scattering Terms Defined
A variety of sources are available to help give a mathematical description of various terms used in light-scattering operations.
Analysing the Particle Size of Cement via Laser Diffraction
The cement production process is typically made up of three distinct stages: preparing the raw mix, producing the clinker, and then grinding the clinker to form the finished cement.
Analysing Polymer Degradation using GPC / SEC Methodology
The effects of processing a polymer has on its molecular weight, molecular weight distribution, and solution viscosity are important for chemical industry manufacturers to understand if they are to fully optimise their operations.
An Analysis of Polymer Branching Using Triple-Detection GPC / SEC
Polymer branching can have a considerable effect on the physical properties of synthesised polymers, including the disruption of crystallinity and increasing chain entanglements and single chain density.
Characterising the Mouthfeel of Chocolate
The unique appeal of chocolate lies in its taste, aroma and mouthfeel / texture; studies have shown that these three attributes combine to create the complex and distinct flavour of chocolate.
Avoiding Particle Sizing Failures When Using Laser Diffraction
Measuring relevant particle size data is an essential process in many industries, due to the way even small variations can alter product performance.
Top Ten Factors to Consider When Purchasing a New DLS Instrument
When investing in a new dynamic light scattering (DLS) instrument, its physical components and technical specifications are obviously important factors to take into account.
Analysing Fuel Filter Efficiency via Online Laser Diffraction
The unwanted introduction of water in diesel fuel is one of the most common cited causes of engine breakdown, and therefore its removal is essential for the safe and efficient operation of diesel engines.
Using GPC / SEC Techniques for Compositional Analysis
As synthetic polymers became more prevalent across the chemicals industry, a desire has arisen to fine-tune the physical properties of these materials in order to optimise the end-products for their intended application.
Use of Polymer Solutions in Inkjet Printing: A GPC / SEC Analysis
Inkjet printing of polymer solutions is an area of interest for depositing precise, high-throughput patterns of functional polymer, with applications that include OLEDs, organic circuits, and textiles.
Implementing OMNISEC Technology in Multi-Detector GPC / SEC Polysaccharide Studies
Polysaccharides are a versatile, naturally-occurring class of materials, and are increasingly used in an array of industrial applications ranging from bio-printing, bioengineering and pharmaceuticals to paper and cotton manufacturing.
How Switching Mobile Phases Can Improve OMNISEC Results
Polylactic acid and polyglycolic acid are biodegradable, thermoplastic materials, and are increasingly being used in a diverse range of industries, for example biomedical applications such as absorbable sutures and medical implant hardware.
Examining the Impact of Particle Characteristics on Suspension Rheology and Product Behaviour
Understanding the behaviour of interactions between dispersed particles in a liquid medium is crucial when it comes to achieving desirable product performance in systems such as ceramics, adhesives and paints.
A Comparison of the Metal Powder Shapes Created By Differing Atomization Processes Using Automated Image Analysis
The manufacture of complex shaped metal parts by Metal Injection Molding (MIM) is a growing industry, and the shape and size of metal powders play an important role in determining process efficiency and properties of the final MIM components.
KBI Biopharma on How Malvern Instruments Aided Their Search for a Commercial Advantage
The KBI Particle Core team needed a tool to help them complete their in-house characterization service by identifying particles they detected in the subvisible and visible size range.
Using Nanoparticle Tracking Analysis to Research Nanobubble Application and Characterisation
The generation, measurement, and applied technologies of so-called nanobubbles, or ultra-fine bubbles, has evolved dramatically in recent years, and their unique properties make them attractive for a number of applications, such as facility cleaning, food disinfection, and water treatment.
Using Squeeze Flow to Extend Rheological Measurements for Concentrated Suspensions
Making shear rheological measurements on samples with a high solids fraction can present difficulties on a rotational rheometer, since the sample can be prone to fracture even at low-medium shear rates.
Time to Harness the True Power of Rheology
Upgrading from a viscometer to a modern rotational rheometer brings access to a range of test methods that can be applied to accelerate and enhance the formulation of personal care products.
Five Compelling Reasons to Replace Sieve Analysis with Laser Diffraction
Sieving remains in use across the manufacturing industry due to its low cost, simplicity, and ability to measure relatively coarse particles up to several centimetres in size.
Number and Volume Size Distributions
The nature of a particle size distribution analysis is dependent upon the manner in which the particles involved are weighted.
Calcium Carbonate Particle Size analysis By Laser Diffraction
The Mastersizer 3000 laser diffraction system can measure particle size from nanometres to millimetres, with measurements over the range being achieved in only a few minutes
Chewing the Fat
Dr Steve Carrington of Malvern Instruments and Prof. D. J. McClements of the University of Massachusetts describe the use of rheology to measure how food changes during mastication and to compare the rheological behaviour of low fat sauces with consumer sensory data for these products.
Component Characterization of Cements using Morphologi G3-ID
Using the Morphologi G3-ID, the size and shape of various components in a cement blend can be individually characterized by morphologically directed Raman analysis.
Reducing Analytical Costs with the Mastersizer 3000
Here, we look at how the Mastersizer 3000, the market-leading laboratory particle size analyzer from Malvern Instruments, can save you time, money and resources, and ultimately deliver a healthy return on investment.
Overcoming and Quantifying ‘Wall Slip’ in Measurements Made on a Rotational Rheometer
When making shear rheological measurements on structured liquids, in particular suspensions, emulsions or foams there is a high probability that the measurement may be affected by a phenomenon known as 'wall slip'
Replacing Viscometers with Rheometers
Rheometer design and functionality has advanced considerably over the course of the last decade and today's instruments offer an extremely broad range of test capabilities, wrapped in software that makes them accessible to less expert users.
Analysing protein stability and storage using Zetasizer Nano ZSP
Spidroins are a unique family of large, structural proteins that make up the bulk of spider silk fibres. The mechanical strength and elasticity of spider silk fibres have led to their successful use in the regeneration of peripheral nerves in rats, with the same properties giving the potential for use in a wide range of other applications.
Evaluating product texture using oscillatory testing on a rotational rheometer
Formulating products to have both the correct functional and sensory attributes can be a difficult task. The latter in particular relies heavily on user feedback which can take considerable time and effort to attain. In addition it is not always easy to interpret such feedback in the context of material properties and hence rheological data.
A Basic Guide to Particle Characterisation
The aim of this guide is to provide a basic grounding in the main particle characterisation techniques currently in use within industry and academia.
Evaluating Product Spreading Characteristics on a Rotational Rheometer Using the Power Law Model
The rheological properties of a product can influence how it is visually and texturally perceived by a consumer and how it is likely to behave during product use.
Analytical Strategies that Reduce the Environmental Impact of Cement Manufacture
Cement is a crucial global commodity, indeed usage levels are a useful indicator of economic activity, but manufacturers have recognized for some years that to safeguard the industry's long-term health, a reduction in impact is essential.
Orthogonal and Complementary Nanoparticle Characterization Techniques
Combining Dynamic Light Scattering with Nanoparticle Tracking Analysis.
NTA: Nanoparticle Toxicity
The use of nanoparticle tracking analysis as a rapid and information-rich multiparameter nanoparticle characterisation technique.
NTA: Environmental Impact of Nanoparticles
NTA in the development of test methods for nanoparticle impact studies.
Polymers are ubiquitous throughout industry, in the form of naturally occurring materials, such as cellulose and starch, and synthetic commodities - polystyrene, polyethylene and nylon, for example.
Kinexus DSR Series: Redefining Rheometer Capabilities for Asphalt Testing
Asphalt, or bitumen, is a petroleum product used in the road, roofing and construction industries.
Upgrading Polymer Characterization From Single to Multi-Detector GPC
Multi-detector gel-permeation chromatography (GPC) is a development over and above single detector systems, which are often called 'conventional GPC'. A single-detector system typically includes a refractive index (RI) detector and is used to make measurements of molecular weight by comparing a sample's elution time against that of standards with known molecular weight.
Control Rheology by Changing Particle Properties
Many common materials can be considered to be dispersions in which one substance (often particulate) is dispersed in another phase. These material types include adhesives, agrochemicals, cement, ceramics, colloids, cosmetics and personal care formulations, food and drink, mining and mineral slurries, paints, inks and surface coatings, pharmaceuticals and polymer systems.
Hydro Sight’s In-Line Insight
Accurately measuring the particle size distribution of a sample relies on various factors. Foremost amongst these is a reliable, high-precision sizing instrument, and equally as important is the successful dispersion of the sample to its constituent primary particles.
Maximising Absolute Molecular Weight via Synthetic Polymers
Malvern's OMNISEC system is a completely new multi-detector GPC system that combines light scattering, refractive index (RI), ultraviolet (UV) and intrinsic viscosity (IV) detectors to generate a large amount of information about a sample simultaneously. Its new design means it is capable of making these measurements with less sample and lower molecular weights than ever before.
The Effect of Carbon Microstructure on Lithium-Ion Batteries
With the upsurge in use of portable electronic devices such as tablets and mobile phones, through to the development of environmentally-friendly electronically powered vehicles, we are experiencing an unprecedented demand for batteries. Developing new, more efficient and more powerful batteries has never been more relevant.
Non-Aqueous Zeta Potential Measurements of Carbon Black Powders
Carbon black nanopowders are widely used in many industrial fields, including ink, paint, and coating applications; asphalt sealants and decorative concrete colorants; textiles and conductive/resistive applications. There are several applications in which the carbon black has to be dispersed in non-aqueous media.
Dependance of Viscosity and Foam Consistency on Gas Volume Fraction
Foams are present in a large number of personal care, food and industrial products.
Nanoparticle Toxicity in Wastewater
The interest of materials and products containing nanoscale structures and engineered nanoparticles has brought up that their longer term potential toxic effects their potential environmental impact.
Using Nanoparticle Tracking Analysis (NTA)
The increasing number of nanomaterial-based products raises concerns about their possible impact on the environment. Suitable methods for their analysis are a particular problem in this regard. This white paper reviews the use of nanoparticle tracking analysis (NTA) in measuring the environmental effects of using nanomaterial wastes and contaminants.
Evaluating Non-Linear Viscoelastic Effects using Normal Force Measurements on a Rotational Rheometer
When viscoelastic materials are deformed, they undergo a three-dimensional deformation, which can be described through a (3x3) tensor.
Predicting the Stability of Dispersions with a Yield Stress
Assessing the long-term stability of a dispersion or emulsion can be both a tedious and time-consuming process; however, it is essential to ensure a product meets quality standards.
Addressing the Needs of Drug Discovery with the MicroCal PEAQ-ITC Instruments
Use of the New Microcal PEAQ-ITC System for Measurement and Characterization of a Broad Range of Protein-LMW Compound Interactions
Measurement and characterization of binding interactions between proteins and lowmolecular weight (LMW) ligands are a focus of academic research and drug discovery.
Microcal ITC Systems: Understanding Biomolecular Interactions
Isothermal titration microcalorimetry (ITC) is an essential tool in drug discovery and the study and regulation of protein interactions. Having been developed specifically to meet the needs of life scientists working in these fields, Malvern MicroCal ITC calorimeters deliver the exceptional performance and outstanding quality data needed in these application areas.
Top Ten Factors to Consider When Buying an Isothermal Titration Calorimeter
The physical components and features of an isothermal titration calorimeter (ITC) instrument and the technical specifications are clearly important to consider when purchasing a new system. However, written specifications can be confusing, misleading and may actually have very little bearing on the actual performance of the instrument.
Malvern Panalytical is pleased to announce the launch of its new range of Morphologi® particle characterisation systems, Morphologi 4 and Morphologi 4-ID.Read more
Malvern Panalytical is pleased to announce the launch of the new Epsilon 4 benchtop analytical tool, which delivers fast and reliable at-line elemental analysis for chemical applications.Read more
February Webinar: An Overview of Dynamic Light Scattering (DLS) for Particle Size Analysis Applications
Dynamic Light Scattering (DLS), alternatively known as either Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering, is an innovative method of analysing the size of small particles within a solution at the sub-micron level.Read more
PANalytical is pleased to announce that the first of the company's 2018 series of webinars will take place on 22 February, focussing on the application study of precision agriculture and spectral signatures.Read more
Malvern is pleased to announce that the company will be demonstrating its innovative new nanoparticle characterisation platform known as NanoSight NS300 at a live launch event, which is set to take place on 18 January.Read more
Malvern Panalytical has announced the launch of a collaborative project that aims to support the development of existing and next generation biopharmaceutical products.Read more
Malvern is pleased to announce that the company will be conducting a webinar entitled 'Transforming the Future of Particle Characterisation: Clarity by Design' on 4 October.Read more
Malvern PANalytical is pleased to announce it will be hosting a webinar entitled 'Rheology of Soft Matter: Gels and Soft Glass Transition' on 14 September.Read more
Leading analytical X-ray instrumentation and software provider PANalytical is pleased to unveil its latest solution, the new Epsilon 1 X-ray fluorescence (XRF) spectrometer.Read more
Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.Read more
Comparative analytical data is at the foundation of any successful biosimilarity programme.Read more
Malvern Instruments will be running two webinar sessions this month; the first will discuss the potential applications of differential scanning calorimetry in protein characterisation, while the second will cover the use of particle size analysis in cement plant operations.Read more
On 21 February, Malvern will host the unveiling of the next major step forward in protein stability characterisation for the regulated environment: the new MicroCal PEAQ-DSC.Read more
The efficiency of a particular powder bed additive manufacturing process, and the overall quality of the finished components, is to a large extent dependent on the packing density and flow behaviour of the metal powders involved.Read more
To celebrate the knowledge, support and dedication of our employees we are introducing our first live panel discussion to help you solve your current challenges. We invite you to write in your questions, comments, feedback and wish lists for our panel to answer.Read more
Optimizing GPC/SEC measurements by Combining High-Performance Columns and Powerful Advanced Detectors
Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for characterizing natural and synthetic polymers.Read more
Best Practices for Characterizing and Manufacturing Battery Slurries and Electrodes – Europe / US Virtual Seminar
The market for batteries is rapidly growing, and the increased demand for portable electronic devices, including mobile phones and laptops requires greater advances in battery technology in order to provide a lightweight, long-lasting and stable power source.Read more
The self-association characteristics of molecules in dilute solutions can provide an assessment of stability at an early stage in development.Read more
Paints or coatings, similar to many commercial products, must be optimized for their end use performance, which for paints and coatings includes leveling behavior, pigment dispersability, sag resistance, applicator loading and film thickness, all of which depend on a coatings rheological behavior.Read more
Malvern has announced it will be demonstrating its new nanoparticle size and concentration measurer NanoSight NS3000, which uses Nanoparticle Tracking Analysis (NTA).Read more
Malvern is to host a webinar about zeta potential and its importance when controlling formulation stability and product performance.Read more
In recent news, the FDA has used key data generated on the Malvern Morphologi G3-ID system to approve the first generic nasal spray drug product containing mometasone furoate. The primary challenge with this approval was proving bioequivalence compared to the innovator product.Read more
Malvern Instruments has launched the new Zetasizer AT, a robust, online, automated analyzer that uses dynamic light scattering (DLS) to automatically measure the size of nanoparticles in suspensions and emulsions.Read more
NanoChOp Project Highlights Value of NanoSight for Monitoring Nanoparticle Characteristics in Biological Systems
Researchers working on the European Metrology Research Project NanoChOp (chemical and optical characterization of nanomaterials in biological systems), funded by EURAMET, have concluded that the NanoSight Nanoparticle tracking analysis system from Malvern Instruments offers unique insight into the behavior of nanoparticles in biological systems.Read more
The latest software release along with an expansion of the global technical specialist team, highlight Malvern Instruments' ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities.Read more
A collaboration between UK firm Malvern Instruments and California-based Bio-Rad has developed new analytical tools for the rapid identification of unknown particles.Read more
Insights shared by William Bernt, director of Particle Characterization Laboratories, highlight the transformative impact of adding a Malvern NanoSight Nanoparticle Tracking Analysis (NTA) system to the analytical toolkit for nanoparticles.Read more
Malvern's new tools for specific analytical challenges in biopharma development will take centre stage at AAPS Annual Meeting and Exposition 2015, in Orlando, US.Read more
Malvern Instruments has established a new biopharmaceutical applications laboratory in the heart of San Diego's biotechnology cluster.Read more
Insight from CP Kelco, a global leader in the speciality hydrocolloids market, provides a blueprint for the intelligent, cost-efficient deployment of gel permeation / size exclusion chromatography (GPC/SEC) in biopolymer manufacture.Read more
Malvern Instruments has launched a new and improved rSolution platform on their Kinexus rotational rheometer to help customers use rheological measurements more effectively.Read more